New Generation of Plasmid Backbones Devoid of Antibiotic Resistance Marker for Gene Therapy Trials

Abstract excerpt

Since it has been established that the injection of plasmid DNA can lead to an efficient expression of a specific protein in vivo, nonviral gene therapy approaches have been considerably improved, allowing clinical trials. However, the use of antibiotic resistance genes as selection markers for plasmid production raises safety concerns which are often pointed out by the regulatory authorities. Indeed, a...

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