Article
Association analysis of canonical Wnt signalling genes in diabetic nephropathy.
PloS one - 1 Jan 2011
Kavanagh David H, Savage David A, Patterson Christopher C, McKnight Amy Jayne, Crean John K, Maxwell Alexander P, McKay Gareth J
Abstract excerpt
AIMS/HYPOTHESIS: Several studies have provided compelling evidence implicating the Wnt signalling pathway in the pathogenesis of diabetic nephropathy. Gene expression profiles associated with renal fibrosis have been attenuated through Wnt pathway modulation in model systems implicating Wnt pathway members as potential therapeutic targets for the treatment of diabetic nephropathy. We assessed tag and potentially...
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