Article
Prediction of drug-resistance in HIV-1 subtype C based on protease sequences from ART naive and first-line treatment failures in North India using genotypic and docking analysis.
Antiviral research - 1 Nov 2011
Toor Jaideep S, Sharma Aman, Kumar Rajender, Gupta Pawan, Garg Prabha, Arora Sunil K
Abstract excerpt
Genotyping reveal emergence of drug resistance (DR)-related mutations in HIV-1 protease (PR) gene in the first-line treatment failure patients as per Stanford DR database. In order to have a subtype C specific prediction model, a three dimensional structure of local wild type C variant is created and the identified mutations were introduced to assess the mutational effects on protease inhibitors (PI) in a...
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