Article
Hyperexcitability in sensory neurons of rats selected for high versus low neuropathic pain phenotype.
Neuroscience - 1 Jan 2001
Liu C N, Raber P, Ziv-Sefer S, Devor M
Abstract excerpt
Selection line rats congenitally high or low for autotomy in the neuroma model of neuropathic pain (HA and LA rats) were found to be correspondingly high and low in a second type of neuropathic pain, the Chung model, which employs an alternative phenotypic endpoint, tactile allodynia. It has been proposed that both phenotypes reflect ectopic hyperexcitability in axotomized primary sensory neurons. To test this...
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