Article
A broadly applicable approach to T cell epitope identification: application to improving tumor associated epitopes and identifying epitopes in complex pathogens.
Journal of immunological methods - 28 Oct 2011
Valentino Michael D, Abdul-Alim C Siddiq, Maben Zachary J, Skrombolas Denise, Hensley Lucinda L, Kawula Thomas H, Dziejman Michelle, Lord Edith M, Frelinger Jeffrey A, Frelinger John G
Abstract excerpt
Epitopes are a hallmark of the antigen specific immune response. The identification and characterization of epitopes is essential for modern immunologic studies, from investigating cellular responses against tumors to understanding host/pathogen interactions especially in the case of bacteria with intracellular residence. Here, we have utilized a novel approach to identify T cell epitopes exploiting the exquisite...
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