Article
Genetic approaches to targeting multiple PARP genes in a mammalian genome.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2011
Meyer-Ficca Mirella L, Meyer Ralph G
Abstract excerpt
The aim of this chapter is to present feasible strategies for producing novel Parp knock out mice as well multiple knock outs utilizing genetrap and specifically gene targeted ES cell clones publically available through international programs such as KOMP and IGTC. Specifically, we first describe general considerations and strategic decisions that precede the generation of knock out mice using these available...
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