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Article

Genomic imprinting at a boundary element flanking the SDHD locus.

Human molecular genetics - 15 Nov 2011

Baysal Bora E, McKay Sharen E, Kim Yoon Jung, Zhang Zimei, Alila Linda, Willett-Brozick Joan E, Pacak Karel, Kim Tae Hoon, Shadel Gerald S

Abstract excerpt

Germline mutations in SDHD, a mitochondrial complex II (succinate dehydrogenase) subunit gene at chromosome band 11q23, cause highly penetrant paraganglioma (PGL) tumors when transmitted through fathers. In contrast, maternal transmission rarely, if ever, leads to tumor development. The mechanism underlying this unusual monogenic tumor predisposition pattern is poorly understood. Here, we describe identification...

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Share to Genomic Imprinting
Share to Chromatin Immunoprecipitation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to DNA Methylation

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Share to Polymorphism, Genetic

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Source

Open in PubMed Open full text

Identifiers

PMID: 21862453
DOI: 10.1093/hmg/ddr376
PMCID: PMC3196894

Genes

SDHD
CTCF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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