Article
Transmission of dapsone-resistant leprosy detected by molecular epidemiological approaches.
Antimicrobial agents and chemotherapy - 1 Nov 2011
Li Wei, Sakamuri Rama M, Lyons Danielle E, Orcullo Florenda M, Shinde Vidyagouri, Dela Pena Edred Lao, Maghanoy Armi A, Mallari Irene B, Tan Esterlina V, Nath Indira, Brennan Patrick J, Balagon Marivic, Vissa Varalakshmi
Abstract excerpt
Drug resistance surveillance identified six untreated leprosy patients in the Philippines with Mycobacterium leprae folP1 mutations which confer dapsone resistance. Five patients share a village of residence; four who carried the mutation, Thr53Val, were also linked by M. leprae variable-number tandem repeat (VNTR) strain types. In India, folP1 mutations were detected in two relapse patients with a history of...
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