Article
Increased ferritin gene expression is associated with increased ribonucleotide reductase gene expression and the establishment of hydroxyurea resistance in mammalian cells.
The Journal of biological chemistry - 5 May 1990
McClarty G A, Chan A K, Choy B K, Wright J A
Abstract excerpt
In the present study, we show that hydroxyurea-inactivated ribonucleotide reductase protein M2 has a destabilized iron center, which readily releases iron. In addition, evidence is presented which indicates that single or multistep selection for hydroxyurea resistance, in a variety of mammalian cell lines, leads to alterations in the expression of the gene for the iron storage protein, ferritin. In all...
Topics
- Animals
- Cell Line
- Cell Survival
- Drug Resistance
- Ferritins
- Gene Expression
- Gene Expression Regulation
- Genes
- Humans
- Hydroxyurea
- Macromolecular Substances