Article
The 9p21 myocardial infarction risk allele increases risk of peripheral artery disease in older people.
Circulation. Cardiovascular genetics - 1 Aug 2009
Cluett Christie, McDermott Mary McGrae, Guralnik Jack, Ferrucci Luigi, Bandinelli Stefania, Miljkovic Iva, Zmuda Joseph M, Li Rongling, Tranah Greg, Harris Tamara, Rice Neil, Henley William, Frayling Timothy M, Murray Anna, Melzer David
Abstract excerpt
BACKGROUND: A common variant at chromosome 9p21 (tagged by the rs1333049 or rs10757278 single-nucleotide polymorphism) is strongly associated with myocardial infarction and major arterial aneurysms. An association with peripheral arterial disease (PAD) was also reported in a sample younger than 75 years, but this disappeared on removal of respondents with a myocardial infarction history, resulting in an odds...
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