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The impact of age on genetic testing decisions in amyotrophic lateral sclerosis

27 Sept 2022

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a heterogeneous neurodegenerative syndrome. In up to 20% of cases, a family history is observed. Although Mendelian disease gene variants are found in apparently sporadic ALS, genetic testing is usually restricted to those with a family history or younger patients with sporadic disease. With the advent of therapies targeting genetic ALS, it is important that everyone...

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PMID: 36162820
DOI: 10.1093/brain/awac279

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