Article
ELK4 neutralization sensitizes glioblastoma to apoptosis through downregulation of the anti-apoptotic protein Mcl-1.
Neuro-oncology - 1 Nov 2011
Day Bryan W, Stringer Brett W, Spanevello Mark D, Charmsaz Sara, Jamieson Paul R, Ensbey Kathleen S, Carter Jacinta C, Cox Joanne M, Ellis Vicky J, Brown Christopher L, Walker David G, Inglis Po L, Allan Suzanne, Reynolds Brent A, Lickliter Jason D, Boyd Andrew W
Abstract excerpt
Glioma is the most common adult primary brain tumor. Its most malignant form, glioblastoma multiforme (GBM), is almost invariably fatal, due in part to the intrinsic resistance of GBM to radiation- and chemotherapy-induced apoptosis. We analyzed B-cell leukemia-2 (Bcl-2) anti-apoptotic proteins in GBM and found myeloid cell leukemia-1 (Mcl-1) to be the highest expressed in the majority of malignant gliomas. Mcl-1...
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