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Abnormal Histone Acetylation and Methylation Levels in Esophageal Squamous Cell Carcinomas

15 Aug 2011

Abstract excerpt

To investigate whether alterations in histone modifications occur in esophageal squamous cell carcinoma (ESCC), we measured histone H3/ H4 acetylation and H3K4/H3K27 methylation levels, as well as the expression of chromatin modifier genes in tumor and healthy esophageal tissue from ESCC patients. We found evidence of global H3 and H4 hypoacetylation, H3K4 and H3K27 hypermethylation in ESCC tissue. Both H3...

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PMID: 21843048
DOI: 10.3109/07357907.2011.597810

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