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Article

A polymorphism of the ABCA1 gene confers susceptibility to schizophrenia and related brain changes.

Progress in neuro-psychopharmacology & biological psychiatry - 1 Dec 2011

Ota Miho, Fujii Takashi, Nemoto Kiyotaka, Tatsumi Masahiko, Moriguchi Yoshiya, Hashimoto Ryota, Sato Noriko, Iwata Nakao, Kunugi Hiroshi

Abstract excerpt

OBJECTIVE: The ATP-binding cassette transporter A1 (ABCA1) mediates cellular cholesterol efflux through the transfer of cholesterol from the inner to the outer layer of the cell membrane and regulates extracellular cholesterol levels in the central nervous system. Several lines of evidence have indicated lipid and myelin abnormalities in schizophrenia. METHOD: Initially, we examined the possible association of...

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Source

Identifiers

PMID: 21839797
DOI: 10.1016/j.pnpbp.2011.07.012

Genes

ABCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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