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Article

Risk Profile of the RET A883F Germline Mutation: An International Collaborative Study.

The Journal of clinical endocrinology and metabolism - 1 Jun 2017

Mathiesen Jes Sloth, Habra Mouhammed Amir, Bassett John Howard Duncan, Choudhury Sirazum Mubin, Balasubramanian Sabapathy Prakash, Howlett Trevor A, Robinson Bruce G, Gimenez-Roqueplo Anne-Paule, Castinetti Frederic, Vestergaard Peter, Frank-Raue Karin

Abstract excerpt

Context: The A883F germline mutation of the rearranged during transfection (RET) proto-oncogene causes multiple endocrine neoplasia 2B. In the revised American Thyroid Association (ATA) guidelines for the management of medullary thyroid carcinoma (MTC), the A883F mutation has been reclassified from the highest to the high-risk level, although no well-defined risk profile for this mutation exists. Objective: To...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28323957
DOI: 10.1210/jc.2016-3640

Genes

RET

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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