Article
Pervasive sign epistasis between conjugative plasmids and drug-resistance chromosomal mutations.
PLoS genetics - 1 Jul 2011
Silva Rui F, Mendonça Sílvia C M, Carvalho Luís M, Reis Ana M, Gordo Isabel, Trindade Sandra, Dionisio Francisco
Abstract excerpt
Multidrug-resistant bacteria arise mostly by the accumulation of plasmids and chromosomal mutations. Typically, these resistant determinants are costly to the bacterial cell. Yet, recently, it has been found that, in Escherichia coli bacterial cells, a mutation conferring resistance to an antibiotic can be advantageous to the bacterial cell if another antibiotic-resistance mutation is already present, a...
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