Article
Catalase rs769214 SNP in elderly malnutrition and during renutrition: is glucagon to blame?
Free radical biology & medicine - 15 Oct 2011
Hebert-Schuster M, Cottart C H, Laguillier-Morizot C, Raynaud-Simon A, Golmard J L, Cynober L, Beaudeux J L, Fabre E E, Nivet-Antoine V
Abstract excerpt
Impaired glucose tolerance is common during aging. The transcription factor PAX6 is involved in glucose homeostasis. Computational promoter sequence analysis of the catalase gene highlighted a putative PAX6 binding site on the rs769214 polymorphism A allele. Creation of this binding site has been suggested to explain renutrition inefficiency in malnourished elderly patients. Our aim was to evaluate the link...
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