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Article

Growth inhibition of human hepatocellular carcinoma cells by overexpression of G-protein-coupled receptor kinase 2.

Journal of cellular physiology - 1 Jun 2012

Wei Zhengyu, Hurtt Reginald, Ciccarelli Michele, Koch Walter J, Doria Cataldo

Abstract excerpt

Hepatocellular carcinoma (HCC) is one of the deadliest forms of human liver cancer and does not respond well to conventional therapies. Novel effective treatments are urgently in need. G-protein-coupled kinase 2 (GRK2) is unique serine/threonine kinase that involves in many signaling pathways and regulates various essential cellular processes. Altered levels of GRK2 have been linked with several human diseases...

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Identifiers

PMID: 21826651
DOI: 10.1002/jcp.22972
PMCID: PMC3908777

Genes

GRK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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