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Article

Vitamin K2 inhibits the proliferation of HepG2 cells by up‐regulating the transcription of <i>p21</i> gene

17 Apr 2007

Abstract excerpt

AIM: Vitamin K2 has been reported to inhibit the growth of human hepatocellular carcinoma (HCC) in vitro and suppress hepatocarcinogenesis in vivo. However, its inhibitory mechanism has not yet been clarified. METHODS: Different concentrations of vitamin K2 (30, 10, 1, 0.1 and 0.01 muM) were added to the HCC cell line HepG2 to assess effects on cell growth. The effect of vitamin K2 on cell cycle progression was...

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PMID: 17441809
DOI: 10.1111/j.1872-034x.2007.00058.x

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