Article
Comparison of drug resistance scores for tipranavir in protease inhibitor-naive patients infected with HIV-1 B and non-B subtypes.
Antimicrobial agents and chemotherapy - 1 Nov 2011
Stürmer Martin, Stephan Christoph, Gute Peter, Knecht Gaby, Bickel Markus, Brodt Hans-Reinhard, Doerr Hans W, Gürtler Lutz, Lecocq Pierre, van Houtte Margriet
Abstract excerpt
Genotypes of samples from protease inhibitor-naïve patients in Frankfurt's HIV Cohort were analyzed with five tipranavir resistance prediction algorithms. Mean scores were higher in non-B than in B subtypes. The proportion of non-B subtypes increased with increasing scores, except in weighted algorithms. Virtual and in vitro phenotype analyses of samples with increased scores showed no reduced tipranavir...
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