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Impaired Parasite Attachment as Fitness Cost of Metronidazole Resistance in Giardia lamblia

9 Aug 2011

Abstract excerpt

Infections with the diarrheagenic protozoan pathogen Giardia lamblia are most commonly treated with metronidazole (Mz). Treatment failures with Mz occur in 10 to 20% of cases and Mz resistance develops in the laboratory, yet clinically, Mz-resistant (Mz(r)) G. lamblia has rarely been isolated from patients. To understand why clinical Mz(r) isolates are rare, we questioned whether Mz resistance entails fitness...

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PMID: 21825286
DOI: 10.1128/aac.00384-11

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