Article
Testing the rate-of-living/oxidative damage theory of aging in the nematode model Caenorhabditis elegans.
Experimental gerontology - 1 Sept 2007
Brys Kristel, Vanfleteren Jacques R, Braeckman Bart P
Abstract excerpt
The integration of the rate-of-living and oxidative damage theory of aging predicts that lifespan extension is linked to low energy metabolism, low ROS production rates, low molecular damage and a slow aging rate. In the long-lived Caenorhabditis elegans Ins/IGF-1 mutant daf-2(e1370), low carbonylation levels and postponed morphological decline comply with the latter two of these predictions. However, metabolic...
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