Article
A canine BCAN microdeletion associated with episodic falling syndrome.
Neurobiology of disease - 1 Jan 2012
Gill Jennifer L, Tsai Kate L, Krey Christa, Noorai Rooksana E, Vanbellinghen Jean-François, Garosi Laurent S, Shelton G Diane, Clark Leigh Anne, Harvey Robert J
Abstract excerpt
Episodic falling syndrome (EFS) is a canine paroxysmal hypertonicity disorder found in Cavalier King Charles spaniels. Episodes are triggered by exercise, stress or excitement and characterized by progressive hypertonicity throughout the thoracic and pelvic limbs, resulting in a characteristic 'deer-stalking' position and/or collapse. We used a genome-wide association strategy to map the EFS locus to a 3.48 Mb...
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