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Article

Reversible aggregation of PABPN1 pre-inclusion structures.

Nucleus (Austin, Tex.) - 1 Jan 2000

Raz Vered, Abraham Tsion, van Zwet Erik W, Dirks Roeland W, Tanke Hans J, van der Maarel Silvère M

Abstract excerpt

Increased aggregation of misfolded proteins is associated with aging, and characterizes a number of neurodegenerative disorders caused by homopolymeric amino acid expansion mutations. PABPN1 is an aggregation-prone nuclear protein. Natural aggregation of wild-type (WT) PABPN1 is not known to be disease-associated, but alanine-expanded PABPN1 (expPABPN1) accumulates in insoluble intranuclear inclusions in muscle...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21818414
DOI: 10.4161/nucl.2.3.15736
PMCID: PMC3149881

Genes

PABPN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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