Article
NOS3 Glu298Asp polymorphism interacts with virgin olive oil phenols to determine the postprandial endothelial function in patients with the metabolic syndrome.
The Journal of clinical endocrinology and metabolism - 1 Oct 2011
Jiménez-Morales Ana I, Ruano Juan, Delgado-Lista Javier, Fernandez Juan M, Camargo Antonio, López-Segura Fernando, Villarraso Javier Caballero, Fuentes-Jiménez Francisco, López-Miranda Jose, Pérez-Jiménez Francisco
Abstract excerpt
BACKGROUND: Glu298Asp polymorphism of the endothelial nitric oxide synthase (eNOS) gene (NOS3) has been characterized as a risk factor of hypertension and coronary artery disease. Previous studies suggest that the higher risk observed in T allele carriers is due to endothelial dysfunction associated with a lower eNOS activity and that acute consumption of phenol-rich olive oil ameliorates postprandial endothelial...
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