Article
Autosomal dominant inheritance of a predisposition to thoracic aortic aneurysms and dissections and intracranial saccular aneurysms.
American journal of medical genetics. Part A - 1 Sept 2011
Regalado Ellen, Medrek Sarah, Tran-Fadulu Van, Guo Dong-Chuan, Pannu Hariyadarshi, Golabbakhsh Hossein, Smart Suzanne, Chen Julia H, Shete Sanjay, Kim Dong H, Stern Ralph, Braverman Alan C, Milewicz Dianna M
Abstract excerpt
A genetic predisposition for thoracic aortic aneurysms and dissections (TAAD) can be inherited in an autosomal dominant manner with decreased penetrance and variable expression. Four genes identified to date for familial TAAD account for approximately 20% of the heritable predisposition. In a cohort of 514 families with two or more members with presumed autosomal dominant TAAD, 48 (9.3%) families have one or more...
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