Article
Familial thoracic aortic aneurysms and dissections: three families with early-onset ascending and descending aortic dissections in women.
American journal of medical genetics. Part A - 1 Jun 2006
Tran-Fadulu Van, Chen Julia H, Lemuth Danielle, Neichoy Bo T, Yuan Jiuhong, Gomes Nathan, Sparks Elizabeth, Kramer Larry A, Guo Dongchuan, Pannu Hariyadarshi, Braverman Alan C, Shete Sanjay, Milewicz Dianna M
Abstract excerpt
Ascending thoracic aortic aneurysms leading to type A dissections can be inherited in an autosomal dominant manner with variable age of onset and decreased penetrance, primarily in women. Three families are described with autosomal dominant inheritance of either ascending aortic aneurysms leading to type A dissections or type B dissections, and a young age of onset of aortic dissections in both men and women....
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