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Article

Defective CFTR expression and function are detectable in blood monocytes: development of a new blood test for cystic fibrosis.

PloS one - 1 Jan 2011

Sorio Claudio, Buffelli Mario, Angiari Chiara, Ettorre Michele, Johansson Jan, Vezzalini Marzia, Viviani Laura, Ricciardi Mario, Verzè Genny, Assael Baroukh Maurice, Melotti Paola

Abstract excerpt

BACKGROUND: Evaluation of cystic fibrosis transmembrane conductance regulator (CFTR) functional activity to assess new therapies and define diagnosis of cystic fibrosis (CF) is cumbersome. It is known that leukocytes express detectable levels of CFTR but the molecule has not been characterized in these cells. In this study we aim at setting up and validating a blood test to evaluate CFTR expression and function...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21811577
DOI: 10.1371/journal.pone.0022212
PMCID: PMC3141019

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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