Functional SNP in the microRNA-367 binding site in the 3'UTR of the calcium channel ryanodine receptor gene 3 (RYR3) affects breast cancer risk and calcification.

doi:10.1073/pnas.1103360108

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Article

Functional SNP in the microRNA-367 binding site in the 3'UTR of the calcium channel ryanodine receptor gene 3 (RYR3) affects breast cancer risk and calcification.

Proceedings of the National Academy of Sciences of the United States of America - 16 Aug 2011

Zhang Lina, Liu Yuexin, Song Fengju, Zheng Hong, Hu Limei, Lu Hong, Liu Peifang, Hao Xishan, Zhang Wei, Chen Kexin

Abstract excerpt

We have evaluated and provided evidence that the ryanodine receptor 3 gene (RYR3), which encodes a large protein that forms a calcium channel, is important for the growth, morphology, and migration of breast cancer cells. A putative binding site for microRNA-367 (miR-367) exists in the 3'UTR of RYR3, and a genetic variant, rs1044129 A→G, is present in this binding region. We confirmed that miR-367 regulates the...

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PMID: 21810988
DOI: 10.1073/pnas.1103360108
PMCID: PMC3158174

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RYR3

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