Article
Genome-wide meta-analysis for serum calcium identifies significantly associated SNPs near the calcium-sensing receptor (CASR) gene.
PLoS genetics - 22 Jul 2010
Kapur Karen, Johnson Toby, Beckmann Noam D, Sehmi Joban, Tanaka Toshiko, Kutalik Zoltán, Styrkarsdottir Unnur, Zhang Weihua, Marek Diana, Gudbjartsson Daniel F, Milaneschi Yuri, Holm Hilma, Diiorio Angelo, Waterworth Dawn, Li Yun, Singleton Andrew B, Bjornsdottir Unnur S, Sigurdsson Gunnar, Hernandez Dena G, Desilva Ranil, Elliott Paul, Eyjolfsson Gudmundur I, Guralnik Jack M, Scott James, Thorsteinsdottir Unnur, Bandinelli Stefania, Chambers John, Stefansson Kari, Waeber Gérard, Ferrucci Luigi, Kooner Jaspal S, Mooser Vincent, Vollenweider Peter, Beckmann Jacques S, Bochud Murielle, Bergmann Sven
Abstract excerpt
Calcium has a pivotal role in biological functions, and serum calcium levels have been associated with numerous disorders of bone and mineral metabolism, as well as with cardiovascular mortality. Here we report results from a genome-wide association study of serum calcium, integrating data from four independent cohorts including a total of 12,865 individuals of European and Indian Asian descent. Our meta-analysis...
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