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Article

Bone morphogenetic protein receptor II is a novel mediator of endothelial nitric-oxide synthase activation.

The Journal of biological chemistry - 23 Sept 2011

Gangopahyay Archana, Oran Max, Bauer Eileen M, Wertz Jeffrey W, Comhair Suzy A, Erzurum Serpil C, Bauer Philip M

Abstract excerpt

Activation of bone morphogenetic protein (BMP) receptor II (BMPRII) promotes pulmonary artery endothelial cell (PAEC) survival, proliferation, and migration. Mutations to BMPRII are associated with the development of pulmonary arterial hypertension (PAH). Endothelial dysfunction, including decreased endothelial nitric-oxide synthase (eNOS) activity and loss of bioactive nitric oxide (NO), plays a prominent role...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21808054
DOI: 10.1074/jbc.M111.274100
PMCID: PMC3190885

Genes

BMP2
BMP4
PAH
BMPR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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