Article
The application of gene co-expression network reconstruction based on CNVs and gene expression microarray data in breast cancer.
Molecular biology reports - 1 Feb 2012
Xu Yan, Duanmu Huizi, Chang Zhiqiang, Zhang Shanzhen, Li Zhenqi, Li Zihui, Liu Yufeng, Li Kening, Qiu Fujun, Li Xia
Abstract excerpt
Copy number variations (CNVs) are one type of the human genetic variations and are pervasive in the human genome. It has been confirmed that they can play a causal role in complex diseases. Previous studies of CNVs focused more on identifying the disease-specific CNV regions or candidate genes on these CNV regions, but less on the synergistic actions between genes on CNV regions and other genes. Our research...
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