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Article

Pronephric Tubulogenesis Requires Daam1-Mediated Planar Cell Polarity Signaling

30 Jul 2011

Abstract excerpt

Canonical β-catenin-mediated Wnt signaling is essential for the induction of nephron development. Noncanonical Wnt/planar cell polarity (PCP) pathways contribute to processes such as cell polarization and cytoskeletal modulation in several tissues. Although PCP components likely establish the plane of polarization in kidney tubulogenesis, whether PCP effectors directly modulate the actin cytoskeleton in...

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PMID: 21804089
DOI: 10.1681/asn.2010101086

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