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Article

Restraint of Fgf8 signaling by retinoic acid signaling is required for proper heart and forelimb formation.

Developmental biology - 1 Oct 2011

Sorrell Mollie R Johnson, Waxman Joshua S

Abstract excerpt

Cardiomelic or heart-hand syndromes include congenital defects affecting both the forelimb and heart, suggesting a hypothesis where similar signals may coordinate their development. In support of this hypothesis, we have recently defined a mechanism by which retinoic acid (RA) signaling acts on the forelimb progenitors to indirectly restrict cardiac cell number. However, we still do not have a complete...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21803036
DOI: 10.1016/j.ydbio.2011.07.022
PMCID: PMC3171575

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