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Article

Interplay Between pVHL and mTORC1 Pathways in Clear-Cell Renal Cell Carcinoma

28 Jul 2011

Abstract excerpt

mTOR complex 1 (mTORC1) is implicated in cell growth control and is extensively regulated. We previously reported that in response to hypoxia, mTORC1 is inhibited by the protein regulated in development and DNA damage response 1 (REDD1). REDD1 is upregulated by hypoxia-inducible factor (HIF)-1, and forced REDD1 expression is sufficient to inhibit mTORC1. REDD1-induced mTORC1 inhibition is dependent on a protein...

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PMID: 21798997
DOI: 10.1158/1541-7786.mcr-11-0302

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