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Article

VHL suppresses RAPTOR and inhibits mTORC1 signaling in clear cell renal cell carcinoma

21 Jul 2021

Abstract excerpt

Inactivation of the tumor suppressor von Hippel-Lindau (VHL) gene is a key event in hereditary and sporadic clear cell renal cell carcinomas (ccRCC). The mechanistic target of rapamycin (mTOR) signaling pathway is a fundamental regulator of cell growth and proliferation, and hyperactivation of mTOR signaling is a common finding in VHL-dependent ccRCC. Deregulation of mTOR signaling correlates with tumor...

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PMID: 34290272
DOI: 10.1038/s41598-021-94132-5

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