Article
Nectins establish a checkerboard-like cellular pattern in the auditory epithelium.
Science (New York, N.Y.) - 26 Aug 2011
Togashi Hideru, Kominami Kanoko, Waseda Masazumi, Komura Hitomi, Miyoshi Jun, Takeichi Masatoshi, Takai Yoshimi
Abstract excerpt
In the auditory epithelium of the cochlea, the sensory hair cells and supporting cells are arranged in a checkerboard-like fashion, but the mechanism underlying this cellular patterning is unclear. We found that mouse hair cells and supporting cells express the immunoglobulin-like adhesion molecules nectin-1 and -3, respectively, and that their interaction mediates the heterotypic adhesion between these two cell...
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