Article
[Application of a model for gene local shuffling in ubiA mutation].
Wei sheng wu xue bao = Acta microbiologica Sinica - 1 Apr 2011
Gu Chao, Fu Nan, Ye Jiang, Zhang Huizhan
Abstract excerpt
UNLABELLED: As a transhydrogen in the mitochondrial respiratory chain, Coenzyme Q (CoQ) has a critical role in the metabolism. 4-hydroxybenzoate polyprenyltransferase (UbiA), which coded by ubiA gene, is the rate-limiting enzyme in the CoQ biosynthesis progress. However, the relationship between structure and function remains unclear. OBJECTIVE: To set up a synthetic oligonucleotide-based shuffling model and...
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