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Article

Correlation analysis for protein evolutionary family based on amino acid position mutations and application in PDZ domain.

PloS one - 6 Oct 2010

Du Qi-Shi, Wang Cheng-Hua, Liao Si-Ming, Huang Ri-Bo

Abstract excerpt

BACKGROUND: It has been widely recognized that the mutations at specific directions are caused by the functional constraints in protein family and the directional mutations at certain positions control the evolutionary direction of the protein family. The mutations at different positions, even distantly separated, are mutually coupled and form an evolutionary network. Finding the controlling mutative positions...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20949088
DOI: 10.1371/journal.pone.0013207
PMCID: PMC2950854

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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