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Article

Conditional Expression of the Androgen Receptor Induces Oncogenic Transformation of the Mouse Prostate

28 Jul 2011

Abstract excerpt

The androgen signaling pathway, mediated through the androgen receptor (AR), is critical in prostate tumorigenesis. However, the precise role of AR in prostate cancer development and progression still remains largely unknown. Specifically, it is unclear whether overexpression of AR is sufficient to induce prostate tumor formation in vivo. Here, we inserted the human AR transgene with a LoxP-stop-loxP (LSL)...

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PMID: 21795710
DOI: 10.1074/jbc.m111.269894

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