Article
FDG-PET imaging, EEG and sleep phenotypes as translational biomarkers for research in Alzheimer's disease.
Biochemical Society transactions - 1 Aug 2011
Platt Bettina, Welch Andy, Riedel Gernot
Abstract excerpt
The lack of reliable translational procedures applicable to both patients and experimental models are a major obstacle for the advancement of basic research as well as for the development of therapeutics. This is particularly relevant to neurodegenerative disorders such as AD (Alzheimer's disease), where the predictive validity of animal models and procedures applied preclinically have met with little success....
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