Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Allelic variants of complement genes associated with dense deposit disease.

Journal of the American Society of Nephrology : JASN - 1 Aug 2011

Abrera-Abeleda Maria Asuncion, Nishimura Carla, Frees Kathy, Jones Michael, Maga Tara, Katz Louis M, Zhang Yuzhou, Smith Richard J H

Abstract excerpt

The alternative pathway of the complement cascade plays a role in the pathogenesis of dense deposit disease (DDD). Deficiency of complement factor H and mutations in CFH associate with the development of DDD, but it is unknown whether allelic variants in other complement genes also associate with this disease. We studied patients with DDD and identified previously unreported sequence alterations in several genes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Biopsy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Complement Activation

Share to Complement C3

Share to Complement System Proteins

Share to Glomerulonephritis, Membranoproliferative

Share to Polymorphism, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 21784901
DOI: 10.1681/ASN.2010080795
PMCID: PMC3148710

Genes

CFH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Allelic variants of complement genes associated with dense deposit disease.PMID 21784901Read ↗

Causes of alternative pathway dysregulation in dense deposit disease.Semantic proximity Read ↗

Lessons from functional and structural analyses of disease-associated genetic variants in the complement alternative pathway.Semantic proximity Read ↗

Genetic control of the alternative pathway of complement in humans and age-related macular degeneration.Semantic proximity Read ↗

Acquired and genetic complement abnormalities play a critical role in dense deposit disease and other C3 glomerulopathies.Semantic proximity Read ↗

Common and rare genetic variants of complement components in human disease.Semantic proximity Read ↗

The spectrum of phenotypes caused by variants in the CFH gene.Semantic proximity Read ↗

Genetic variability shapes the alternative pathway complement activity and predisposition to complement-related diseases.Semantic proximity Read ↗

Human C3 mutation reveals a mechanism of dense deposit disease pathogenesis and provides insights into complement activation and regulation.Semantic proximity Read ↗

Complement Gene Variants Define the Conformational Dynamics of C3 Convertase.Semantic proximity Read ↗

Variations in the complement regulatory genes factor H (CFH) and factor H related 5 (CFHR5) are associated with membranoproliferative glomerulonephritis type II (dense deposit disease).Semantic proximity Read ↗

C3 glomerulopathy: the genetic and clinical findings in dense deposit disease and C3 glomerulonephritis.Semantic proximity Read ↗

Dense deposit disease: new insights.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.