Article
Detection of IDH1 mutations and the status of MGMT promoter on intraoperative fresh tissue section from frameless neuronavigation needle biopsy. Analysis on 17 patients with brain glial tumor ineligible for craniotomy and tumor resection.
International journal of immunopathology and pharmacology - 1 Jan 2000
Iaccarino I, Nicoli D, Serra S, Froio E, Pisanello A, De Berti G, Ghadirpour R, Marcello N, Servadei F, Carinci F
Abstract excerpt
It is well known that primary and secondary glioblastomas are histologically largely indistinguishable. Therefore, the detection of IDH1 mutations or the status of the MGMT promoter on a simple bioptic sample could be one of major diagnostic and prognostic importance for glial patients that complements clinical criteria for distinguishing secondary from primary glioblastomas and to predict a more favourable...
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