Article
DMT1 polymorphism and risk of Parkinson's disease.
Neuroscience letters - 1 Sept 2011
He Qing, Du Tingting, Yu Xiaojun, Xie Anmu, Song Ning, Kang Qi, Yu Jintai, Tan Lan, Xie Junxia, Jiang Hong
Abstract excerpt
Growing evidence suggests that iron accumulation in the substantia nigra (SN) is involved in the pathology of Parkinson's diseases (PD). Divalent metal transporter 1 (DMT1) is an endogenous transporter for ferrous iron, the levels of which are significantly increased in the SN in postmortem PD brains. To study the possible association of DMT1 gene with PD occurrence, one mutation (1303C/A) and two single...
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