Article
Filaggrin loss-of-function mutation R501X and 2282del4 carrier status is associated with fissured skin on the hands: results from a cross-sectional population study.
The British journal of dermatology - 1 Jan 2012
Thyssen J P, Ross-Hansen K, Johansen J D, Zachariae C, Carlsen B C, Linneberg A, Bisgaard H, Carson C G, Nielsen N H, Meldgaard M, Szecsi P B, Stender S, Menné T
Abstract excerpt
BACKGROUND: Filaggrin metabolites act as osmolytes and are important for skin hydration. Carriers of filaggrin loss-of-function mutations have a higher prevalence of atopic dermatitis and dry skin. There is also evidence to suggest that filaggrin mutations increase the risk of hand eczema in atopic individuals. In our clinic, we have observed a distinct phenotype of hand eczema in patients with filaggrin mutation...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.