Article
Genetic variations in the interleukin-21 gene and the risk of recurrent idiopathic spontaneous miscarriage.
European cytokine network - 1 Jun 2011
Messaoudi Safia, Al-Khateeb Ghada M, Dendana Maryam, Sater Mai S, Jazia Khaled B, Nouira Mounia, Almawi Wassim Y, Mahjoub Touhami
Abstract excerpt
OBJECTIVES: Insofar as recurrent spontaneous miscarriage (RSM) is linked with dysregulated immunity and inflammatory changes, and given the pro-inflammatory role of interleukin-21 (IL-21), we examined the association between IL-21 polymorphisms and RSM. METHODS AND RESULTS: IL-21 rs2055979, rs13143866, rs9992580, and rs4833837 were genotyped in 235 cases of RSM and 235 controls. Regression analysis was employed...
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