Article
Contribution of JAK2 and STAT3 variants to the genetic susceptibility of recurrent spontaneous miscarriage in a Tunisian population.
Genetic testing and molecular biomarkers - 1 Jan 2013
Messaoudi Safia, Hizem Sondes, Al-Sulaiti Manar A, Al-Busaidi Amna S, Magdoud Kalthoum, Dendana Maryam, Almawi Wassim Y, Mahjoub Touhami
Abstract excerpt
AIMS: Th1 and Th2 balance is crucial for maintenance of pregnancy, and intracellular JAK and STAT proteins significantly contribute to it. In view of evidence linking JAK2 and STAT3 variants with recurrent spontaneous miscarriage (RSM), here we investigated the association of JAK2 (rs2230724) and STAT3 (rs1053023 and rs1053004) to RSM susceptibility in Tunisians. SUBJECTS AND METHODS: A retrospective case-control...
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