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Article

EGFR exon 20 insertion mutations in non-small-cell lung cancer: preclinical data and clinical implications.

The Lancet. Oncology - 1 Jan 2012

Yasuda Hiroyuki, Kobayashi Susumu, Costa Daniel B

Abstract excerpt

Lung cancer is the leading cause of cancer-related death. The identification of epidermal growth factor receptor (EGFR) somatic mutations defined a new, molecularly classified subgroup of non-small-cell lung cancer (NSCLC). Classic EGFR activating mutations, such as inframe deletions in exon 19 or the Leu858Arg (L858R) point mutation in exon 21 are associated with sensitivity to first generation quinazoline...

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Source

Identifiers

PMID: 21764376
DOI: 10.1016/S1470-2045(11)70129-2

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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