Article
Epigenetic and genetic components of height regulation.
Nature communications - 16 Nov 2016
Benonisdottir Stefania, Oddsson Asmundur, Helgason Agnar, Kristjansson Ragnar P, Sveinbjornsson Gardar, Oskarsdottir Arna, Thorleifsson Gudmar, Davidsson Olafur B, Arnadottir Gudny A, Sulem Gerald, Jensson Brynjar O, Holm Hilma, Alexandersson Kristjan F, Tryggvadottir Laufey, Walters G Bragi, Gudjonsson Sigurjon A, Ward Lucas D, Sigurdsson Jon K, Iordache Paul D, Frigge Michael L, Rafnar Thorunn, Kong Augustine, Masson Gisli, Helgason Hannes, Thorsteinsdottir Unnur, Gudbjartsson Daniel F, Sulem Patrick, Stefansson Kari
Abstract excerpt
Adult height is a highly heritable trait. Here we identified 31.6 million sequence variants by whole-genome sequencing of 8,453 Icelanders and tested them for association with adult height by imputing them into 88,835 Icelanders. Here we discovered 13 novel height associations by testing four different models including parent-of-origin (|β|=0.4-10.6 cm). The minor alleles of three parent-of-origin signals...
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