Article
LINGO1 gene analysis in Parkinson's disease phenotypes.
Movement disorders : official journal of the Movement Disorder Society - 1 Mar 2011
Lorenzo-Betancor Oswaldo, Samaranch Lluís, García-Martín Elena, Cervantes Sebastián, Agúndez José A G, Jiménez-Jiménez Félix J, Alonso-Navarro Hortensia, Luengo Antonio, Coria Francisco, Lorenzo Elena, Irigoyen Jaione, Pastor Pau
Abstract excerpt
BACKGROUND: Parkinson's disease (PD) and essential tremor (ET) may share some etiopathogenic factors. A genome-wide association study has shown that LINGO1 gene variants are associated with increased risk of ET. We hypothesized that LINGO1 variants could increase susceptibility to PD. METHODS: A large series of PD subjects and healthy controls were genotyped for rs9652490 and rs11856808 LINGO1 single nucleotide...
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